The Risks of ARIA-E in DINANAMAP

The side effect that is most concerning is something called amyloid-related imaging abnormalities. ARIA manifests as MRI changes or hemorrhages, typically microbleeds but occasionally macrohemergies. These occurred in higher proportion of patients treated with the drug than in placebo. The risk of ARIA, in particular, ARIA-E, is highly related to an individual's apolipoprotein E genotype.