33. The ID:IOTs Guide to Aminoglycosides
ID:IOTS - Infectious Disease Insight Of Two Specialists
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Understanding Aminoglycosides: Mechanism, Coverage, and Resistance
This chapter explores the mechanism of action of aminoglycosides like Gentamicin, detailing how they interact with bacterial ribosomes and impact cell membrane polarity. It compares Gentamicin and Tobramycin in terms of bacterial coverage and delves into resistance mechanisms, particularly focusing on modifying enzymes and efflux pumps. The discussion also covers the pharmacokinetics and pharmacodynamics of aminoglycosides, highlighting their localized effects, dosing strategies, and efficacy in different infections.
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