Management of Severe Acetaminophen Toxicity

This chapter delves into the comprehensive management of severe acetaminophen (Tylenol) toxicity in critically ill patients, addressing challenges in diagnosis, specific lab tests for identification, and evolving NAC dosing protocols. The discussion emphasizes the need for early intervention, considerations for NAC administration based on clinical suspicion, and potential risks associated with NAC use in high acetaminophen concentrations. The chapter also explores the nuanced considerations in employing charcoal, lavage, and whole bowel irrigation in cases of massive acetaminophen ingestions, highlighting the factors influencing treatment decisions and potential outcomes.