Navigating Biotech Challenges

Follow us at signal.nucleate.xyz

2:23 Raj describes growing up in India as a land of hustlers and the importance of being aggressive to advance oneself.

6:37 Discusses the challenges of the current biotech funding environment and the importance of being capital efficient.

11:17 Explains his career transition from large pharma to biotech, highlighting his ability to translate breakthrough science into products.

21:11 Describes founding Rectify Pharmaceuticals and building a platform for positive functional modulators targeting membrane proteins.

25:08 Explains the company's pivot to focusing on hepatobiliary diseases, particularly primary sclerosing cholangitis (PSC).

33:00 Emphasizes the importance of relationships, mentorship, and getting feedback from various stakeholders in building a successful biotech company.

56:46 Discusses how they initially vetted the Rectify platform by extensively researching ABC transporters and developing screening assays. 

1:05:21 Highlights the courage to explore broader applications of their platform beyond rare monogenic diseases.

1:12:44 Provides final advice for entrepreneurs, stressing the importance of having a detailed plan, being realistic, and building a strong founding team.