Studying Interneuron Migration in Human Development with Cortical Assembloids

The chapter delves into a nature paper exploring the role of neurodevelopmental disease genes in abnormal interneuron migration related to autism spectrum disorder using cortical organoids and assembloids. Through a massive CRISPR screen, researchers identified candidate genes like CSDE1 and SMAD4 influencing interneuron development. The chapter showcases the power of CRISPR screens and the versatility of assembloids in dissecting mechanisms underlying neurodevelopmental disorders.