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The Grand Theory of the Brain
I think we could be looking for a really good model that explains how the basil ganglia work. The brain is doing so many different things wit so many different parts. It's just not clear that there'd be some global theory that would give you both respiration and memory of your grandmother from 50 years ago. That, to me, is an example of what i think is a big general principle: every cell in the brain has to solve this problem of how to control its intrinsic excitability.