EP 130: Quarterly insights into noncoding variants and GWAS with Dr. Veera Rajagopal
The Genetics Podcast
00:00
Unraveling Genetic Variants and Evolutionary Implications
Exploring the historical context and evolutionary reasoning behind a prevalent genetic variant, the chapter delves into the evolution of GWAS studies with large sample sizes to decipher disease mechanisms. It highlights challenges in reaching saturation for binary traits while making progress in identifying risk variants for quantitative traits like height. Innovative approaches in analyzing genome-wide significant variants for diseases like type 2 diabetes are discussed, emphasizing the importance of pathway-specific risk scores and precision medicine in understanding genetic makeup for tailored treatments.
Transcript
Play full episode
