Understanding HLA Match Platelet Safety and Strategies

Have you ever looked at your wallet after a big night out and seen that all your dollars have been conjugated to alloantibodies and phagocytosed by macrophages? Then you know what it’s like to transfuse a platelet refractory patient! Join us as we take a tour of platelet refractoriness and do our best to find some HLA-matched dollars for rent this week.

Timestamps

00:52 - Bashar lives near a nuclear reactor
2:03 - Clinical case
5:38 - Defining platelet refractoriness
7:46 - Calculating platelet increments
12:42 - Causes of refractoriness
18:10 - Immune mechanisms of refractoriness
21:23 - HLA in detail
25:03 - HPA antigens
27:39 - Testing
31:46 - The Luminex assay
34:00 - Managing immune refractoriness
43:26 - Take home messages

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