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Chris Masterjohn: The Best Ways To Optimize Your Diet & Nutrition | Episode 16

The Joe Cohen Show

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Biotin and Metabolic Catastrophe

There's this collection of biotin disorders. All of these respond to high doses of biotin. The reason can be can vary from the enzyme that uses it has a low affinity. And so you need a very high dose just to get normal levels, right? If you find someone who's seven years old with some kind of metabolic catastrophe and there's all kinds of measurable things wrong in their urine... It generally takes months for all the markers to normalize. But if you give them a high dose, you're going to saturate the system much more quickly. You might achieve that same benefit way faster by bringing up to one milligram a day. That's not necessarily a pharmac

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