Intro

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🕑 Timestamps:

0:00:00 - 0:13:37 – Epigenetics, Methylation, And Aging

0:13:37 - 0:19:02 – Books That Have Dramatically Impacted Peter’s Life. His Current Career Goals.

0:19:02 - 0:22:42 – Sponsor: Eight Sleep (The Most Impactful Sleep Enhancing Device I Have Ever Used)

0:22:44 - 0:29:50 – AI, And Why Peter Typically Doesn’t Find Tests That Look For Early ASCVD Valuable

0:29:50 - 0:32:12 – Is There An APOB Level That Guarantees No Risk Of Atherosclerosis?

0:32:12 - 0:33:27 – For Those With Hypofunctioning PCSK9 And Extremely Low LDL-C, What Is Their Average Age Of Death, And What Are They Dying From?

0:33:27 - 0:35:06 – How Much Cholesterol Is Needed For Brain Development?

0:35:06 - 0:36:22 – How Lipid Managing Medications Work

0:36:22 - 0:41:16 – How Peter Evaluates The Best Strategy For Managing APOB For Each Patient

0:41:16 - 0:42:39 – Can You Trust Grocery Store Olive Oil?

0:42:39 - 0:44:09 – Is Olive Oil Healthier Than Eating Less?

0:44:09 - 0:47:56 – If You’re Thriving With Bad Lipids, What Should You Do?

0:47:56 - 0:49:34 – Are Statins Evil?

0:49:34 - 0:53:00 – Tests For Targeted Lipid Management

0:53:00 - 0:56:28 – Bempedoic Acid Vs. Statins

0:56:28 - 1:00:03 – Peter’s Multipronged Approach To Lipid Managing Pharmacology

1:00:03 - 1:05:22 – Sponsor: Marek Health (Preventive Medicine, HRT, & Rigorous Blood Work)

1:05:22 - 1:06:45 – Liver Toxicity And NAFLD

1:06:45 - 1:08:57 – Which Statins Are The Most Likely To Cause Side Effects?

1:08:57 - 1:10:49 – Repatha

1:10:49 - 1:14:04 – Will Obicetrapib Obliterate Atherosclerosis?

1:14:04 - 1:17:47 – Medications That Lower Lp(a)

1:17:47 - 1:25:01 – If Someone Has High Lp(a), But Excellent Metabolic Health, Can They Still Develop Premature Heart Disease?

1:25:01 - 1:26:50 – The Reason Why We Develop Plaque In Arteries, But Not Veins

1:26:50 - 1:27:33 – Maintain ≤ 120/80 Blood Pressure To Smash Your Risk Of Heart Disease And Dementia

1:27:33 - 1:28:34 – Is Lower Than 120/80 Better?

1:28:34 - 1:31:49 – How To Fix High Blood Pressure

1:31:49 - 1:34:12 – DEXA Scans And What A “Good” FFMI Is

1:34:12 - 1:36:24 – Is There Any Way To Verify Endothelial Damage?

1:36:24 - 1:38:16 – How Helpful Is A CT Angiogram?

1:38:16 - 1:40:06 – Can You Accurately Detect Plaque Accumulation In Yearly Intervals With CT Angiography?

1:40:06 - 1:43:47 – Why You Can Have No Detectable Inflammation In Bloodwork, But Still Develop Raging Atherosclerosis

1:43:47 - 1:51:24 – Why Peter Is Starting HRT, And What His Protocol Will Be

1:51:24 - 2:00:47 – Women’s Birth Control Options

2:00:47 - 2:05:42 – When Should Women Start HRT?

2:05:42 - 2:15:48 – Optimizing Women’s HRT Protocols

2:15:48 - 2:18:51 – The Prevalence Of Hypothyroidism

2:18:51 - 2:22:09 – When Should You Treat Inflammation With Supplements Or Medications?

2:22:09 - 2:24:48 – Will Cold Plunge Pre-Workout Inhibit Muscle Growth?

2:24:48 - 2:25:43 – Cold Plunge Increases Dopamine As Much As Coke!?

2:25:43 - 2:30:54 – Peter’s Use Of Modafinil, Nicotine, Caffeine, And What He Thinks The Best Nootropic Is

2:30:54 - 2:33:29 – How To Properly Dose Omega-3 Supplements

2:33:29 - 2:38:30 – Sponsor: Gorilla Mind (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations)

2:38:30 - 2:42:33 – What Actually Causes Brain Fog?

2:42:33 - 2:46:36 – How Obesity Impacts Mitochondrial Function

2:46:36 - 2:48:38 – Ideal Daily Magnesium Intake

2:48:38 - 2:51:42 – What Are The Most Important Sleep Metrics?

2:51:42 - 3:22:27 – F1 Talk

3:22:27 - 3:30:26 – Reconnecting Peter Attia With His Long-Lost Obsession... Tearing Phone Books!

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