Mutation of the Ubiquitin Ligase

I don't think we're far enough along yet in the clinical development to know how big of a problem resistance is going to turn out to be. I think it's you could almost be guaranteed that there will be resistance, because that that just arises ind cantser to most any kind of drug. You could imagine resistance arisinga in two very general ways. One is through mutation of the binding sit that the that the small molecule santo on the target, or mutation of thebinding site that the other side of the heterobi functional molecule, binds to.