Freely Filtered 028: Finerenone for diabetic kidney disease
Freely Filtered, a NephJC Podcast
Is There a Difference Between Primary and Secondary Composite Kidney Outcomes?
There was no difference as you predicted George in all come mortality between the two groups. There were also no difference in hospitalization for any cause. But if you get to that secondary composite kidney outcome, which is basically a doubling of serum creatinine or sustained decrease of 57% in GFR or reaching kidney failure or kidney death, there. The effect size here is greater than the primary composite outcome. This presumably more difficult barrier to cross. It's a 0.76 odds hazard ratio versus 0.82. That's impressive. And in fact, in terms of size of effect, it is almost identical to what we saw in Brenner's and Lewis's IDNT and Renau.
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