The Effects of Fezzolintant on Hot Flushes and Hot Sweat

Fezzolintant is a new treatment for vasomotor symptoms associated with menopause. A part of the brain produces a molecule called neurokinin B, and this molecule is involved in the motor neuron pathways that end up in a hot flush. In normal temperature control, if we get hot, if we overheat, our blood vessels dilate through those motor pathways to allow heat release. The opposite happens when we're cold. Neurokinin B is basically telling the brain to tell the body we're hot and release heat. That's what happens in these sort of vasomotor episodes. And women experience them differently. Some women will say they feel very hot and go very