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Ep. 97: “Viral Structures” Featuring Dr. Erica Saphire

The Immunology Podcast

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The Power of Cryo-Electron Microscopy in Structural Biology

This chapter explores the revolutionary impact of cryo-electron microscopy (cryo-EM) on understanding protein structures and functions. It compares cryo-EM to traditional x-ray crystallography, highlighting its ability to capture dynamic and heterogeneous biological molecules in their native state. The discussion also includes applications of cryo-EM in studying viral proteins, emphasizing its pivotal role in elucidating molecular interactions crucial for immune responses.

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