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Ask a Nobel Scientist: 2022 Bay Area Winners in Chemistry and Physics Take Your Questions

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How Do You Think About Chemical Chemistry?

Bio-orthogonal chemistry is a new way of looking at molecules and their reactivities. It's based on the idea that if you make a molecule with this shape it should have this type of reactivity. The first step intellectually is to take inventory of all the kinds of chemicals that exist in a biological setting like in our bodies. Then we try to design chemicals that are not at all related to what's within us would not interact or interfere with anything that's within us but just live a parallel life.

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