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Steve Hsu Q&A: Complex trait prediction in Genomics, and Genomic Prediction / Embryo Selection

Manifold

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Is There a Zero Sum Competition Between Disease Risks?

The index has a number of really interesting properties. It turns out there are some mild positive internal correlations of the disease risks within the index that basically kind of yoa free lunch. We discovered that, contrary to many expectations of negative or competitive pliotrope, that means that trying to make you healthier on one disease risk makes you less healthy on another. Do we have any idea why would evolution have optimized us to have higher over all disease risks? Lyke, do we no know what these gens that seem to increase risk of multiple ace tas our doing?

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