The Link Between VO2 Max and Brain Health

How can we protect our brain as we age and what can we do today to boost memory, focus, and resilience?

In this episode of The Proof, I’ve compiled some of the most impactful conversations I’ve had with leading neuroscientists, neurologists, and brain health researchers to explore exactly that.

From building better habits to slowing age-related decline, this masterclass brings you practical, science-backed strategies for optimising brain function, now and in the future.

Whether your goal is sharper mental clarity, prevention of neurodegenerative disease, or simply staying sharp for the long haul, this episode is packed with insights you can use right away.

You’ll learn:

• How neuroplasticity allows your brain to adapt and change at any age

• The role of movement and VO₂ max in protecting cognitive performance

• How omega-3s and dietary fats impact brain structure and function

• What APOE4 means for your risk of Alzheimer’s and why genetics aren’t destiny

• The link between cardiovascular health, lipoproteins, and dementia

• How the microbiome and inflammation influence brain aging

• The surprising ways exercise improves brain volume and connectivity

• Why creatine isn’t just for muscles and how it may enhance mental energy and mood

• Actionable daily habits to reduce your risk of cognitive decline

• The truth about lifestyle vs genetics when it comes to Alzheimer’s disease

Featuring insights from Dr Andrew Huberman, Dr Ayesha Sherzai, Dr Dean Sherzai, Dr Thomas Dayspring, and Dr Kellyann Niotis, this episode distills cutting-edge neuroscience into clear, practical guidance for long-term cognitive health.

Thank you for tuning in to today’s episode, and special thanks to the experts featured for their invaluable insights. If you found this episode helpful, please share it with someone who you think might benefit from it.

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Simon Hill, MSc, BSc (Hons)

• Creator of theproof.com

• Host of The Proof with Simon Hill

• Author of The Proof is in the Plants

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