Carolyn Bertozzi and Degrading Drugs for Problematic Proteins
Raising Health
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MANOS 6-Phosphate Receptor - How to Degrade a Protein
So nature has already come up with a way to degrade the proteins that are membrane associated and extracellular. And one of the best known lysosomal trafficking receptors is the so-called MANOS 6-phosphate receptor. So you need a binding molecule that is very specific and ideally also very high affinity against your target of interest. We made a lie tag out of a human drug called satuximab. It's an antibody against EGFR that is used in the oncology setting. But we're interested in the epidermal growth factor receptor as a target for degradation. This is an important cancer target, EGFR. it's overexpressed or mutated in
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