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#50 - Acute catabolic (yes, catabolic...) response of bone to exercise with Dr Wendy Kohrt

Inside Exercise

CHAPTER

The Paradox of PTH and Bone Mass

PTH is an unusual hormone. It actually has paradoxical actions on bone. If it's elevated chronically, like in primary or secondary hyperparathyroidism, people who have that condition almost always develop osteoporosis. So chronically elevated PTH is toxic to bone. But if the increase in PTH is transient, it is then anabolic to bone. And I don't know of any studies in humans, but in animal studies, the critical factor seems to be the duration of time PTH is elevated. That seems to be when it transitions from being anabolic to catabolic.

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