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Manual Therapy
The big knock I think against manual therapy, is that nobody understands the mechanisms. There's actually quite a few animal and human research studies that show that there is a bio true biological mechanism that occurs with a manual therapy technique. Most of them if you think about this are we're talking about a 20 minute thing. Manual therapy has been shown to influence blood chemistry levels of those in animals and humans. The strongest dopamine literature is with soft tissue mobilization which I would argue is a form of manual therapy.