4 lifestyle changes that lower high blood pressure | Dr Sanjay Gupta
ZOE Science & Nutrition
The gut microbiome connection
Sarah describes microbiome signatures linked to blood pressure and how microbes and inflammation may influence vessels.
High blood pressure is the number one risk factor for deaths globally. But what if your blood pressure numbers were only part of that story?
In this episode, we’re joined by leading cardiologist Dr Sanjay Gupta, who explains why blood pressure is not a disease, but often a scream for help.
Together with ZOE’s Chief Scientist, Professor Sarah Berry, he explores when blood pressure is a harmless response to stress, food, or movement, and when it signals real, long-term damage. You’ll learn why blood pressure targets aren’t universal, why worrying can make things worse, and why quality of life matters as much as numbers.
This episode also breaks down what you can do to lower your blood pressure. Not quick fixes. Not pills. But everyday lifestyle changes that address the root cause.
If your blood pressure is your body sending a message, what might it be asking you to change?
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Timecodes
00:00 Intro
03:40 What blood pressure really is
09:10 The damage builds slowly (and you won’t feel it)
11:00 The two numbers explained in plain English
13:05 Why the ‘right’ number depends on you
15:04 Why doctors can’t agree on ‘high’
16:35 The first rule: don’t panic
17:45 The clinic reading problem
20:20 The misdiagnosis issue
22:02 What high blood pressure can damage
23:40 Why problems show up years later
24:30 How common is high blood pressure?
27:00 The ‘silent killer’ warning signs
28:10 The bigger cause most people miss
29:10 Salt: why it helps some people more than others
33:30 The age effect most people ignore
35:11 How stress can push blood pressure up
36:35 The gut microbiome link (and the new research)
39:15 Why treatment can still fail
40:10 The uncomfortable numbers on medication benefit
41:15 The simple home-measurement routine
44:05 Sugar vs salt: what surprised the cardiologist
46:45 Where most salt really comes from
49:25 The exercise effect (and why it matters)
51:05 How fast lifestyle changes can show up
📚Books by our ZOE Scientists
Every Body Should Know This by Dr Federica Amati
Food For Life by Prof. Tim Spector
Free resources from ZOE
How to eat in 2026 - Discover ZOE’s 8 nutrition principles for long-term health
Live Healthier: Top 10 Tips From ZOE Science & Nutrition
Gut Guide - For a Healthier Microbiome in Weeks
Mentioned in today's episode
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Gut microbiome diversity and hypertension, Journal of Hypertension (2021)
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Ultra-processed food raises risk of heart disease, heart attack and stroke, BHF (2023)
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Potassium and blood pressure, British Journal of Nutrition (2010)
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Episode transcripts are available here.
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