Intro

• Whether David Perlmutter and Rick Johnson are right about fructose and uric acid being drivers of poor metabolic health

• Why fructose will not cause ATP depletion when it’s consumed in normal contexts

• Why fructose and uric acid are not the drivers of metabolic syndrome and degenerative conditions

• The protective effects of fructose in the liver

• Why it’s extremely important to consider the different contexts in which uric acid is produced

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Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-84-fructose-and-uric-acid-are-david-perlmutter-and-rick-johnson-wrong-part-1/ 

Timestamps:

3:56 – why we’re discussing fructose and uric acid

8:38 – the general argument that fructose consumption drives uric acid production and that this is responsible for disease and degeneration

14:48 – our general counterargument that fructose consumption does not drive disease and degeneration via uric acid production

18:41 – whether fructose depletes ATP in the liver 

30:03 – fructose is extremely protective and generally increases ATP availability in the liver 

36:27 – how fructose can increase uric acid via ATP depletion

38:51 – why fructose doesn’t cause ATP depletion and uric acid production unless it’s given in extreme, non-physiologically relevant contexts

1:04:50 – whether uric acid is the driver of metabolic syndrome and many degenerative conditions by driving oxidative stress 

1:15:46 – why xanthine oxidase is a major confounding variable to consider when evaluating whether uric acid production is harmful

1:27:02 – whether the activation of AMP deaminase is a reason not to consume fructose

1:27:55 – average fructose intakes are far below the amounts that are typically used in research