Methadone: Should We Use It More?

Methadone is actually an incredibly effective medication perioperatively and yet we don't use it very much. There's a small percentage of Caucasian patients that are aren't great cyp 2d6 metabolizers so rotating opioids instead of increasing doses can be beneficial. Even using a small amount of methadone even as short as once a day almost works like a little boost to the advocacy of other opiates but i'm not sure we fully figure that out yet.