Alpha Thalassemia Major and Hemoglobin Barts

In H B H, you'll have red cell inclusions because of those beta tetramers precipitating. You can use molecular studies to confirm whether it's a deletion or non-deletional form. And finally, what about alpha thalassemia major or hemoglobin barts? In this condition, you have deletion of all four alphas. Both of the patient parents have to be alpha zero carriers for this to occur.