Specific CD8+ T cell clones in ITP, Refining DLBCL prognosis with the “dark-zone signature”, and rethinking the regenerative role of HSCs in acute hematopoietic emergencies
Blood Podcast
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The Double-Hit Signature for Dark-Zone Lymphoma
Researchers evaluated biopsies using FISH, immunohistochemistry and digital gene expression profiling to categorize DL-BCLs. A key finding this research article is that the double-hit signature goes beyond HGBCL to identify dark-zone lymphomas. Dark-zone positive had the poorest outcomes, including a two-year overall survival of just 57 percent. The field may need to reflect on what is the most meaningful method for classifying DLLBCL.
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