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Ep. 70: “Public Outreach” Featuring Drs. Akiko Iwasaki and Aimee Bernard

The Immunology Podcast

CHAPTER

Understanding T Cell Suppressive Function in Tumor Immunity

Exploring the acquisition of suppressive function by conventional T cells in tumors, the chapter addresses the challenges in targeting regulatory T cells for cancer immunotherapy. It discusses the emergence of new suppressive T cell populations post-depletion and the role of IL10 in mediating suppression. Additionally, it explores alternative approaches like depleting CCR8 positive cells and combining IL10 inhibition with therapies for improved tumor control.

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