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The Cambrian Explosion
Darwin's theory has been progressively disconfirmed by multiple observations in multiple subdisciplines of biology. The fossil record looks very different than Darwin anticipated that it would look. He depicted the history of life as a great branching tree where the forms of life we see today emerged gradually from one or very few simple forms at the base of the tree, at the trunk of the tree. But instead what we see is an orchard of separate trees with no connections to those ancestral precursors or forms. There are multiple instances of this type of abrupt appearance.