Intro

Today, we will be diving into Moderna. Founded in 2010, Moderna and its innovative RNA platform made headlines after developing one of the first COVID vaccines. We treated this Breakdown slightly different than our other episodes. I’m joined today by two guests. First, I am joined by Jason Kelly, CEO of Gingko Bioworks. He gives us a primer on the biotech industry, genetic modification, and how Moderna’s platform represents a new breakthrough in the industry. Then, I talk to Matthew Harrison, a biotech analyst at Morgan Stanley. We will cover what differentiates Moderna’s business model, how Moderna’s science could lead to faster and higher efficacy drug development, and key takeaways for investors and operators. I hope you enjoy this Breakdown of Moderna.

For the full show notes, transcript, and links to the best content to learn more, check out the episode page here.

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Show Notes - Part 1: Jason Kelly

[00:02:31] - [First question] - What is a biotech company?

[00:03:50] - Defining Moderna as a company in the biotech space

[00:05:15] - Bridging the gap between biotech and genentech

[00:06:02] - Overview of the history of learning to program cells

[00:07:46] - Big milestones from the discovery to the human genome project

[00:10:03] - Technical process and tool of how one modifies and copies genes

[00:11:45] - The scale and tools of modern DNA design

[00:14:05] - What the Moderna vaccine is and how it works

[00:17:24] - The first engineered drug of its kind 

[00:18:24] - Other areas where synthetic biology appears in everyday life

[00:22:19] - How many sectors this type of technology will disrupt

[00:23:32] - The history of Moderna and how they came to be

[00:24:41] - What problem Moderna tries to solve and how they approach it

[00:27:11] - Unique deal components in therapeutics and the FDA

[00:29:06] - Key factors that will make Moderna a dominant player in the near future 

[00:30:01] - How Genentech became as big as they did 

[00:30:53] - Competitive and compounded advantages for biotech companies

[00:32:09] - Lessons for investors and entrepreneurs in studying Moderna’s story

Show Notes - Part 2: Matthew Harrison 

[00:34:10] - What is Moderna and how it got started

[00:36:10] - Typical route taken for a drug maker and how Moderna is different

[00:37:16] - What separates Moderna from others in the biotech space today

[00:39:12] - The role software and technology has played a role in Moderna’s success

[00:41:42] - Cementing their position through breakthroughs and capitalizing on them 

[00:42:58] - How Moderna generates their revenue 

[00:44:45] - Overview of cost of sales, expense buckets and gross margin

[00:46:20] - Factors involved in how one valuates a biotech company

[00:47:15] - How many drugs are in Moderna’s pipeline compared to others

[00:51:26] - Risks of drug development and their market potential

[00:54:01] - Internal operations of drug development and what separates Moderna

[00:57:17] - Comparing Moderna’s mRNA to others on the market 

[00:59:44] - High level breakdown of pharmaceutical R&D

[01:01:33] - Other P&L and financial components that arise given the nature of biotech 

[01:03:09] - Contrast between the Moderna and Pfizer vaccine

[01:04:18] - What Moderna will have to get right in order to become the next Pfizer 

[01:05:38] - What Moderna would have to get wrong to limit their growth

[01:07:24] - Company culture and the importance of management

[01:08:06] - Lessons for builders and entrepreneurs in studying Moderna’s story