TWiV 955: Clinical update with Dr. Daniel Griffin
This Week in Virology
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In his weekly clinical update Dr. Griffin discusses the four things to know about RSV, the burden of respiratory syncytial virus in healthy term-born infants in Europe, the diagnostic accuracy of rapid diagnostic tests for Ebola virus disease, evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox, tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations, acute and postacute sequelae associated with SARS-CoV-2 reinfection, clinical course of SARS-CoV-2 infection and recovery in lung transplant recipients, effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy, maternal antibody response and transplacental transfer following SARS-CoV-2 infection or vaccination in pregnancy, impact of community masking on COVID-19, Lifting Universal Masking in Schools – Covid-19 Incidence among Students and Staff, systematic review of the clinical effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 in immunocompromised patients, comparative effectiveness of sotrovimab and molnupiravir for prevention of severe COVID-19 outcomes in patients in the community, early adoption of anti–SARS-CoV-2 pharmacotherapies among us veterans with mild to moderate COVID-19, evaluation of viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants, monoclonal antibodies for treatment of SARS-CoV-2 infection during pregnancy, twice daily oral zinc in the treatment of patients with COVID-19, cognitive deficits in long Covid-19, severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration, and long-lasting symptoms after an acute COVID-19 infection and factors associated with their resolution.
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Links for this episode- Four things to know about RSV (Gates Foundation)
- The burden of RSV in healthy term-born infants in Europe (The Lancet)
- Diagnostic accuracy of rapid tests for Ebola (CMI)
- Accuracy of self-collected swabs for diagnosis of Monkeypox (CID)
- Tecovirimat is effective against human monkeypox virus in vitro (Nature)
- Acute and postacute sequelae associated with SARS-CoV-2 reinfection (NatureMedicine)
- SARS-CoV-2 infection and recovery in lung transplant recipients (Transplant Infectious Diseases)
- Effectiveness of third COVID-19 vaccination during pregnancy (Nature Communications)
- Maternal antibody response and transplacental transfer following infection or vaccination (CID)
- Impact of community masking on COVID-19 (Science)
- Lifting universal masking in schools (NEJM)
- Bebtelovimab fact sheet for providers (FDA)
- Effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 (medRxiv)
- Effectiveness of Sotrovimab and Molnupiravir for prevention of severe COVID-19 outcomes (BMJ)
- Early adoption of Anti–SARS-CoV-2 pharmacotherapies among US veterans (JAMA)
- PAXLOVID patient eligibility screening checklist (FDA)
- Viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants (medRxiv)
- Monoclonal antibodies for treatment of SARS-CoV-2 during pregnancy (Annals of Internal Medicine)
- Remdesivir fact sheet for providers (Veklury)
- Twice daily oral zinc in the treatment of patients with COVID-19 (CID)
- Cognitive deficits in long COVID-19 (NEJM)
- Severe Neuro-COVID associated with peripheral immune signatures, autoimmunity and neurodegeneration (Nature Communications)
- Long-lasting symptoms after an acute COVID-19 Infection (JAMA)
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- Dr. Griffin’s treatment guide (pdf)
- Letters read on TWiV 955
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
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