For years, breast cancer has been classified as either HER2-positive or HER2-negative, determining whether a patient could receive HER2-targeted therapies like trastuzumab (Herceptin). However, a growing body of research suggests a middle category—HER2-low breast cancer—which has led to important changes in how clinicians approach treatment.
A recent review published in Oncotarget, titled “Evolving Concepts in HER2-Low Breast Cancer: Genomic Insights, Definitions, and Treatment Paradigms,” explores what this means for both patients and clinicians.
Full blog - https://www.oncotarget.org/2025/02/12/her2-low-breast-cancer-a-new-understanding/
Paper DOI - https://doi.org/10.18632/oncotarget.28680
Correspondence to - Andrew A. Davis - aadavis@wustl.edu
Video short - https://www.youtube.com/watch?v=dn54UrHCUNQ
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Keywords - cancer, breast cancer, HER2-low, genomics
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Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.
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