TWiV 955: Clinical update with Dr. Daniel Griffin
This Week in Virology
SARS-CoV-2 Vaccination in Pregnancy
In Massachusetts, many school districts lifted masking requirements during the subsequent weeks. Lifting of masks was associated with an additional 45 cases per thousand students and staff. Districts that chose to sustain a masking requirement longer tended to have school buildings that were older in worse condition than those that did not.
In his weekly clinical update Dr. Griffin discusses the four things to know about RSV, the burden of respiratory syncytial virus in healthy term-born infants in Europe, the diagnostic accuracy of rapid diagnostic tests for Ebola virus disease, evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox, tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations, acute and postacute sequelae associated with SARS-CoV-2 reinfection, clinical course of SARS-CoV-2 infection and recovery in lung transplant recipients, effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy, maternal antibody response and transplacental transfer following SARS-CoV-2 infection or vaccination in pregnancy, impact of community masking on COVID-19, Lifting Universal Masking in Schools – Covid-19 Incidence among Students and Staff, systematic review of the clinical effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 in immunocompromised patients, comparative effectiveness of sotrovimab and molnupiravir for prevention of severe COVID-19 outcomes in patients in the community, early adoption of anti–SARS-CoV-2 pharmacotherapies among us veterans with mild to moderate COVID-19, evaluation of viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants, monoclonal antibodies for treatment of SARS-CoV-2 infection during pregnancy, twice daily oral zinc in the treatment of patients with COVID-19, cognitive deficits in long Covid-19, severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration, and long-lasting symptoms after an acute COVID-19 infection and factors associated with their resolution.
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Links for this episode- Four things to know about RSV (Gates Foundation)
- The burden of RSV in healthy term-born infants in Europe (The Lancet)
- Diagnostic accuracy of rapid tests for Ebola (CMI)
- Accuracy of self-collected swabs for diagnosis of Monkeypox (CID)
- Tecovirimat is effective against human monkeypox virus in vitro (Nature)
- Acute and postacute sequelae associated with SARS-CoV-2 reinfection (NatureMedicine)
- SARS-CoV-2 infection and recovery in lung transplant recipients (Transplant Infectious Diseases)
- Effectiveness of third COVID-19 vaccination during pregnancy (Nature Communications)
- Maternal antibody response and transplacental transfer following infection or vaccination (CID)
- Impact of community masking on COVID-19 (Science)
- Lifting universal masking in schools (NEJM)
- Bebtelovimab fact sheet for providers (FDA)
- Effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 (medRxiv)
- Effectiveness of Sotrovimab and Molnupiravir for prevention of severe COVID-19 outcomes (BMJ)
- Early adoption of Anti–SARS-CoV-2 pharmacotherapies among US veterans (JAMA)
- PAXLOVID patient eligibility screening checklist (FDA)
- Viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants (medRxiv)
- Monoclonal antibodies for treatment of SARS-CoV-2 during pregnancy (Annals of Internal Medicine)
- Remdesivir fact sheet for providers (Veklury)
- Twice daily oral zinc in the treatment of patients with COVID-19 (CID)
- Cognitive deficits in long COVID-19 (NEJM)
- Severe Neuro-COVID associated with peripheral immune signatures, autoimmunity and neurodegeneration (Nature Communications)
- Long-lasting symptoms after an acute COVID-19 Infection (JAMA)
- Contribute to our MicrobeTV fundraiser at PWB
- Dr. Griffin’s treatment guide (pdf)
- Letters read on TWiV 955
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
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