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Ep. 92: “Cell Death and Immunity” Featuring Dr. Pascal Meier

The Immunology Podcast

CHAPTER

Unraveling Treg Dynamics in Cancer Immunotherapy

This chapter investigates the pivotal role of regulatory T cells (Tregs) in cancer and autoimmune responses, highlighting recent findings on tumor-specific CD4 T cells. It explores the therapeutic potential of manipulating T-BET expression and transient Treg depletion to enhance immune responses in tumor settings. Additionally, the chapter emphasizes innovative CAR T-cell strategies, such as T-Rex constructs, which aim to mitigate risks like graft-versus-host disease while improving anti-tumor effectiveness.

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