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Challenges and Strategies in Dosing Antiepileptic Medications
The chapter examines the complexities of dosing antiepileptic medications in critically ill patients, focusing on weight-based dosing, dose caps, and pharmacokinetics of drugs like phenytoin and valproic acid. It discusses dosing adjustments based on patient weight, implications of exceeding dose caps, and the importance of optimal dosing strategies in critical care settings. The chapter also explores the impact of home anti-seizure medication, speed of administration, effectiveness of different agents, and the significance of the ESET trial in treating status epilepticus.