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iwAL 2023 Session I: Clonal hematopoiesis in AML, early detection and potential therapeutics

VJHemOnc Podcast

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Interactions between somatic and germline variants in patients with germline predisposition syndromes

This chapter discusses the potential interaction between somatic and germline variants in patients with germline predisposition syndromes, using the example of a germline RUNKS1 mutation and its association with myeloid malignancy. It also explores the acquisition of somatic mutations and clonal evolution as markers for identifying patients at higher risk for developing myeloid malignancy.

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