In this episode, Thomas Seyfried, a cancer researcher and professor of biology at Boston College, discusses a controversial view of cancer as a mitochondrial metabolic disease. Many topics related to the causes, treatments, and prevention of cancer are covered in this in-depth conversation.
We discuss:
- How Tom got interested in cancer research [9:00];
- Calorie-restricted ketogenic diets, fasting, and epileptic seizures [18:30];
- Otto Warburg and the Warburg effect [30:45];
- Germline mutations, somatic mutations, and no mutations [42:00];
- Mitochondrial substrate level phosphorylation: Warburg’s missing link [51:30];
- What is the structural defect in the mitochondria in cancer? [1:02:00];
- Peter’s near-death experience with the insulin suppression test while in ketosis [1:06:30];
- Insulin potentiation therapy and glutamine inhibition [1:13:15];
- The macrophage fusion-hybrid theory of metastasis [1:39:30];
- How are cancer cells growth dysregulated without a mutation? [1:47:00];
- What is the dream clinical trial to test the hypothesis that we can reduce the death rates of cancer by 50%? [2:03:15];
- How can the hypothesis be tested rigorously that structural abnormalities in the mitochondria impair respiration and lead to compensatory fermentation? [2:26:30];
- Case studies of GBM survivors [2:32:45]; and
- More.
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