The Nine Markers of Aging

The initial nine hallmarks of aging were: epigenetic changes, impaired proteostasis, stem cell dysfunction and mitochondrial dysfunction. The author of that paper has updated it with three additional hallmarks - inflammation, gut dysbiosis and impaired autophagy. "Many of the big things that we'll talk about that you can do will ultimately affect several of these," he says.

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While you may be familiar with the nine hallmarks of aging, over the past several years there have been an additional five added to that list. It might seem overwhelming to have 14 aging processes to keep up with, but it's important to understand that many of them, if not all of them, are essentially interrelated.

One thing we’ve learned about these processes that drive aging are that they are done at a cellular and systemic level. This gives us the opportunity to try and intercept and correct them so that we can live longer, healthier lives.

I’m joined by Leslie Kenny, Founder of Oxford Healthspan and Co-Founder of the Oxford Longevity Project. We’re talking all about the hallmarks of aging, including how the processes are interconnected, and what we can do to slow these processes down. We also dive into polyamines, specifically spermidine, and how it can boost autophagy.

Leslie Kenny is an autoimmune survivor/thriver, certified health coach and Founder and CEO of Oxford Healthspan, bringing to consumers the latest scientifically based molecules proven to slow aging.

She is also the Co-Founder of the non-profit Oxford Longevity Project which aims to bring the latest scientific breakthroughs on healthy aging to the general public. Leslie holds degrees from Berkeley and Harvard.

What we discuss:

00:01:38 - The symposiums and organizations Leslie is connected to

00:11:21 - The first nine hallmarks of aging

00:15:25 - Inflammation, gut dysbiosis, and autophagy

00:22:22 - The effects of fasting on the body

00:30:09 - The dysregulated RNA process

00:36:03 - What are polyamines?

00:44:42 - How do people get polyamines into their diet?

00:51:40 - Synthetics vs. food derived

00:57:17 - The benefits of spermidine supplements

Key Takeaways:

Polyamines are derived from amino acids, and they play a role in slowing down the process of aging. The most well known polyamine is spermidine, and it helps to boost autophagy.
There are many other molecules in foods and whole food sources, so it is important to consume nutrients through eating whole foods.
The body is able to regenerate and self renew itself if we're able to remove the obstacles and facilitate those processes.
Leslie’s top suggestions for longevity include eating intentionally, joyful movement, sleep, and early morning sunlight.

Find more from Nathalie:

YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ

Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance

Instagram: https://www.instagram.com/nathalieniddam/

Website: NatNiddam.com

Join Nat’s Membership Community: https://www.natniddam.com/bsp-community

Work with Nat: Book Your 20 MInute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08

Find more from Leslie Kenny:

Website: www.oxfordhealthspan.com

Instagram: @oxfordhealthspan, @lesliesnewprime, @oxfordlongevityproject

LinkedIn: https://www.linkedin.com/company/68855978

https://www.linkedin.com/company/oxford-longevity-project/