Why the Endocannabinoid System Matters

Discover how decoding your DNA can unlock the full potential of plant medicine. This episode delivers a cannabis masterclass for biohackers, revealing how personalized genetics are transforming human performance, brain optimization, and longevity. You’ll learn how to identify your ideal cannabis and supplement protocols, balance your endocannabinoid system, and turn precision data into powerful healing. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Len May, MSc, visionary authority in personalized medicine and CEO of EndoDNA, the world leader in DNA-based wellness technology. With over 25 years of pioneering work in genomics, epigenetics, and medicinal cannabis, Len’s patented DNA decoding system maps your unique genotypes to design tailor-made health solutions. His company holds the world’s largest real-world efficacy database in precision wellness, integrating functional medicine, AI-driven analytics, and genetic data to create personalized blueprints for optimal brain function and performance. 

Together, Dave and Len explore how your genetic code determines how you respond to cannabis, psychedelics, nootropics, and supplements—and how to use that data to reduce anxiety, improve sleep optimization, and enhance focus. You’ll learn how decoding your DNA can guide anti-aging strategies, mitochondrial performance, metabolism, and neuroplasticity, revealing new ways to live longer and smarter. 

This episode dives deep into the intersection of cannabis science, genomics, and biohacking. You’ll discover how genetic polymorphisms influence mood, cognition, and stress response, and how personalized medicine can help you make smarter decisions around ketosis, fasting, and recovery. From optimizing the endocannabinoid system to hacking your biology for resilience and longevity, this is the future of functional medicine in action. 

You’ll Learn: 

• How the endocannabinoid system regulates mood, focus, pain, and stress response 

• Which genetic polymorphisms affect cannabis sensitivity, anxiety risk, and dosing windows 

• How to use DNA testing to select cannabinoid and terpene ratios that fit your biology 

• Why delivery method matters and when sublingual dosing outperforms inhalation 

• How personalized cannabis protocols can support sleep optimization, recovery, and emotional regulation 

• The role of cannabinoids in mitochondrial function, neuroplasticity, and cognitive performance 

• How pharmacogenomics reduces antidepressant side effects and improves treatment matching 

• How to screen genetics for safer psychedelic use and avoid adverse reactions 

• What HLA and related markers reveal about mold sensitivity and inflammation 

This is essential listening for anyone serious about biohacking, brain optimization, longevity, anti-aging, functional medicine, and living Smarter Not Harder—with precision tools designed to upgrade your mind and body at the genetic level. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: cannabis biohacking, cannabis masterclass, Dave Asprey cannabis, DNA decoding, genetic testing for cannabis, personalized medicine, endocannabinoid system, cannabis genomics, cannabis and DNA, cannabis and genetics, cannabis nootropics, plant medicine biohacking, cannabis brain optimization, cannabis and neuroplasticity, cannabis for focus, cannabis and mitochondria, cannabis metabolism, cannabis for sleep, cannabis anti-aging, precision wellness, functional medicine, cannabis longevity, EndoDNA, Len May, cannabis and AI, biohacking genetics, cannabis and fasting, cannabis and ketosis, personalized supplements, cannabis and mood, cannabis stress response, genetic biohacking, cannabis cognitive performance 

Thank you to our sponsors! 

-Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. 

-Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. 

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. 

-iRestore | Use code DAVE at https://www.irestore.com/ to unlock an exclusive discount on the iRestore Elite. 

Resources:  

• Danger Coffee: https://dangercoffee.com/discount/dave15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

• 0:00 – Trailer 

• 1:25 – Introduction 

• 7:02 – Cannabis & The Endocannabinoid System 

• 13:30 – How It Works 

• 21:38 – Brain Health & Clinical Studies 

• 26:52 – Psychedelics & Genetic Testing 

• 31:37 – Genetics vs Epigenetics 

• 34:53 – Antidepressant Safety 

• 40:41 – Cannabis Success Stories 

• 46:02 – ADHD & Personality Genes 

• 50:54 – Mold, Nicotine & Mitochondria 

• 55:27 – GLP-1 & Metabolism 

• 1:00:34 – Microbiome & Medical Freedom 

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