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Oncology Today with Dr Neil Love: Key Presentations in Acute Myeloid Leukemia and Myelodysplastic Syndromes from the 2022 ASH Annual Meeting

Hematologic Oncology Update

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Is It Related to Cytokine Side Effects?

The mechanism action of lusperisps is to be a trap of cytokines, which are believed to promote anemia in MDS. Ruxellatin probably works that way for some people with malifibrosis. It does turn down the Jaxtat pathway, which is a proinflammatory pathway and it what's inflammation, but cytokines. The trick is to just get rid of the negative cytokines without getting rid of the ones that help you prevent from dying from gram negative sepsis.

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