Steve Hsu Q&A: Complex trait prediction in Genomics, and Genomic Prediction / Embryo Selection
Manifold
Is There a Genetic Basis for Breast Cancer?
There are specific genetic mutations called b r c a mutations, which predispose women for breast cancer. The most widely understood aspect of it is specific, single gen mutations that are not polygenic in nature. But we may have to add up the impact of thousands of these individual common genetic variants in order to estimate the total breast cancer risk. That can only be done through machine learning. It's got to be done by machine learning on many tens of thousands of women who have had breast cancer and for whom we have their genomes. And then some controls, maybe hundreds of thousands of controls, who did not have breast cancer in their lives, and we have their genoms.
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