Lorezzodone: A Breakthrough in Bipolar Depression

Lorezzodone was the first antipsychotic to treat depression without any help from antidepressants or antidepressant-like molecules. How would accomplish this is not clear, but here are some possibilities. Most of these antipsychotics hit their antidepressant targets in the lower dose range. As the dose goes up, dopamine blockade kicks in more and that's where you see a risk of causing depression.