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Is It Cross-Reactive Enough for the New Antigen?
If you put the new antigen in, if it's close enough to the old one that it cross reacts. Will that interfere with making new B cells? He's saying yes, because they are seeing a blip in new antibodies that goes away quickly. And when you boost, it looks not so well boosted. They still would have memory B cells to the new antigen that need additional time. It was all focused on the original.