In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden interviews Dr. Mariza Snyder about perimenopause and hormone replacement therapy. Dr. Mariza shares her personal experience with perimenopause and her mother's struggle with severe mood changes. They discuss the impact of stress on hormone levels and the importance of progesterone in maintaining hormonal balance. They also touch on the remodeling of the brain during perimenopause and the potential benefits of hormone replacement therapy in reducing the risk of dementia. In this conversation, Dr. Mariza and Dr. Gladden discuss the use of hormone replacement therapy (HRT) for women experiencing perimenopause and menopause. They emphasize the importance of treating the individual rather than relying solely on lab results. Dr. Mariza shares her recommendation on when to test women during their menstrual cycle. They also discuss the potential for extending longevity by developing molecules that enable ovaries to function longer. They highlight the significance of lifestyle factors, such as metabolic health, inflammatory markers, and nutrient profiles, in optimizing women's health. Additionally, they touch on the importance of monitoring cancer risk and managing hormone metabolism through gut health and liver detox pathways. They stress the need for comprehensive testing and individualized treatment plans to ensure the safe and effective use of hormone replacement therapy.

Takeaways

· Perimenopause is a time of hormonal transition for women, typically starting in their late 30s or early 40s.

· Symptoms of perimenopause can include mood swings, anxiety, brain fog, heavy periods, bloating, and sleep issues.

· Progesterone plays a crucial role in maintaining hormonal balance and can help alleviate symptoms of perimenopause.

· Hormone replacement therapy, including progesterone supplementation, may be beneficial in optimizing hormone levels and reducing the risk of dementia.

· The remodeling of the brain during perimenopause can have significant impacts on a woman's overall health and well-being. Hormone replacement therapy (HRT) can be beneficial for women experiencing perimenopause and menopause.

· Treating the individual and monitoring symptoms is important, rather than relying solely on lab results.

· Testing hormone levels, including estrogen metabolism, progesterone, estradiol, estrone, testosterone, and DHEA, can provide valuable insights.

· Lifestyle factors, such as metabolic health, inflammatory markers, and nutrient profiles, play a significant role in women's overall health.

· Monitoring cancer risk and optimizing hormone metabolism through gut health and liver detox pathways is crucial.

· Comprehensive testing and individualized treatment plans are necessary for safe and effective hormone replacement therapy.

Chapters

00:00 Introduction and Personal Experience with Perimenopause

11:57 The Role of Progesterone in Balancing Hormones

30:00 Delaying Menopause and Extending Longevity

To follow Dr. Mariza and her work or reach out to her:

· Facebook: https://www.facebook.com/drmarizasnyder/

· Instagram: https://instagram.com/drmariza/

· YouTube: https://www.youtube.com/user/drmarizasnyder

· Twitter: https://twitter.com/DrMariza

· Website: https://www.drmariza.com/

· Email: mariza@drmariza.com

For the audience:

· Dr. Mariza wants to gift you the Women's Metabolic Assessment Guide + Functional Lab Ranges! Get it here → https://drmariza.com/metabolicassessment

· Use the code 'Podcast10' to get 10% OFF your order at our supplement store → https://gladdenlongevityshop.com/

Reach out to us:

Website: https://gladdenlongevity.com/

Email: podcast@gladdenlongevity.com

Facebook: https://www.facebook.com/Gladdenlongevity/

Instagram: https://www.instagram.com/gladdenlongevity/?hl=en

LinkedIn: https://www.linkedin.com/company/gladdenlongevity

YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw

Gladden Longevity Podcast Disclosures

Production & Independence

The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas.

Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements.

Medical Disclaimer

The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content.

The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options.

Use of information from this podcast and any linked materials is at the listener's own risk.

Podcast Guest Disclosures

Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team.

Sponsorships & Affiliate Disclosures

To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes.

We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented.

Additional Note on Content Integrity

All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.

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