Exploring the Impact of Gut Health on Thyroid Crystals and Musculoskeletal Pain

Your everyday habits might be accelerating aging, and this episode reveals what to do instead. You’ll learn how specific plants trigger powerful longevity pathways and how to eliminate the hidden toxins disrupting your hormones, brain, mitochondria, and overall health. This is a masterclass in biohacking from two experts who’ve spent decades researching how to upgrade the human body. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey is joined by Darin Olien, environmental health expert, bestselling author of Fatal Conveniences, and co-host of the Netflix series Down to Earth with Zac Efron. Darin has traveled the globe uncovering forgotten plant compounds, investigated the most overlooked environmental toxins, and now works with leading scientists and governments to bring these breakthroughs into functional medicine and human performance. 

Together, they break down: 

• How rare plant compounds like osmotin support adiponectin and mitochondrial repair 

• Why PFAS, synthetic fragrances, and EMFs are sabotaging your biology 

• How environmental toxins contribute to hormone disruption and infertility 

• What makes tap water so dangerous and how to fix it with simple filtration 

• Why microplastics and heavy metals are harder to avoid than ever 

• The role of habit design, detox protocols, and indoor air quality in biohacking longevity 

• Why removing toxins first leads to better results in fasting, ketosis, nootropics, and cold therapy 

This episode delivers practical tools for building resilience, improving detox capacity, and navigating the modern world with awareness. You’ll also get insights into the systems that have failed to protect public health and how personal action can create collective change. 

If you’re interested in senolytics, sleep optimization, neurohacking, and smarter ways to upgrade your environment, you’ll find those topics explored in depth throughout this channel. 

Whether you’re detoxing from hidden toxins or optimizing with Danger Coffee, this conversation aligns with the core principles of Smarter Not Harder and the mission of Upgrade Labs. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

SPONSORS: 

-OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. 

-Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.  

-Apollo Neuro | To get an Apollo wearable, go to https://apolloneuro.com/Dave and save 15%. 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Darin’s Website – https://superlife.com/ 

• Darin’s Instagram: https://www.instagram.com/darinolien/ 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 Trailer 

• 01:10 Intro 

• 02:14 Meet Darin Olien 

• 04:26 Wildfires and Pollution 

• 07:13 PFAS and Everyday Toxins 

• 12:37 Corporate and Regulatory Failure 

• 26:36 Synthetic Fragrances 

• 36:12 Water and Air Filtration 

• 36:53 Indoor Air Quality 

• 38:33 Building Healthy Habits 

• 40:05 Essential Oils and Hormones 

• 41:54 Tofu, Tempeh, and Estrogen 

• 46:34 Adiponectin and Biohacking 

• 47:04 Osmotin for Longevity 

• 49:48 Stem Cells and Repair 

• 53:57 Communicating Science 

• 01:04:12 Nutrition and the Microbiome 

• 01:06:14 Final Thoughts 

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