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Freely Filtered 057: NephMadness 2023 TMA
Freely Filtered, a NephJC Podcast
Transplant Question With TMA - Is There a Genetic Mutation in TMA?
In general drug-induced TMA is a very small percentage have complement defects but in the transplant world it's different. There could be a small subset of patients where tach is just the trigger and these actually ended up having a genetic mutation underlying. If you know that there is a genetic mutation I don't particularly stop the tach in these patients now if it's an older patient maybe because they're not as sensitive to rejection. But younger patients with mutations and TMA are more likely to reject their transplants. And then switching them to Bella which puts them at bigger risk of rejections more particularly AMRs and then AMR itself is a TMA trigger.
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