The Dogma Surrounding Cholesterol and Atherosclerosis

Time Stamps:

00:00:00 - Peter Attia’s new book ‘Outlive’

00:02:26 - Who is Peter Attia? What is Medicine 3.0?

00:03:28 - Peter Attia’s career. How did he become a doctor? And how did he evolve into his unique approach to preventative medicine?

00:07:54 - What do the acronyms in Peter’s Instagram bio stand for?

00:13:53 - The Four Horseman of Death (most will die from one of these)

00:22:46 - How to not die from atherosclerotic disease (the leading cause of death)

00:29:59 - The impact of smoking on atherosclerotic disease

00:30:36 - The impact of high blood pressure (hypertension) on atherosclerotic disease, how common it really is, and how to track it

00:32:32 - The accuracy of manual vs. automatic blood pressure cuffs

00:35:41 - The impact of APOB/all atherogenic particles (LDL’s, LP(a)’s, VLDL’s, and IDL’s) on atherosclerotic disease

00:40:57 - The minimum APOB level needed for adequate function

00:42:43 - PCSK-9 gene and its effect on LDL. How PCSK-9 inhibitors work to lower LDL

00:43:24 - APOB vs. APOA

00:44:56 - The most effective lipid managing dr*gs for preventing atherosclerosis

00:50:16 - Why Peter doesn’t see a reason why anybody should have an APOB over 60 mg/dL

00:52:15 - If Peter could go back in time knowing what he knows now and with modern pharmacology, at what age would he start lowering his APOB

00:55:04 - Arterial plaque accumulation starts as early as when you are a teenager. Calcification takes years to show up on a coronary CT calcium scan, but that does not mean plaque isn’t accumulating

00:57:12 - Should you screen for atherosclerosis before taking medication? If so, how? 

01:01:06 - Why are carnivore diet zealots so dogmatic about cholesterol and atherosclerosis? What does the data show to date?

01:06:05 - If those with average genetics maintain a near perfect diet, exercise regimen and sleep hygiene, will many of those individuals still develop atherosclerosis?

01:09:41 - How to lower blood pressure

01:13:25 - Sleep Apnea and the use of CPAP

01:16:49 - Cancer: Causes, Prevention, and Proactive Screening 

01:35:53 - The devices and metrics Peter uses to track his sleep and recovery

01:41:50 - Resting heart rate, HRV, heart rate recovery, and how predictive they are of mortality

01:44:43 - Peter's full daily routine and diet

01:54:35 - Why Peter stopped fasting

01:57:12 - Bodybuilders abuse of T3, Clen, DNP, and other metabolic modulators

01:58:54 - Peter breaks down his 6000+ calorie diet, 6 hours of daily exercise, and the most absurd meals he ate to maintain his weight when he was younger

02:01:25 - How Peter’s kids eat. How strict should the diet be for your kids when it comes to food quality to maximize growth potential?

02:07:41 - Where is the best burger in Austin?

02:08:22 - What time Peter stops eating each night, and the hack he uses to prevent him from overeating

02:11:33 - Peter's non-negotiable nightly practices for maximizing sleep quality

02:12:31 - Why Peter has a Bat phone

02:14:29 - How to live in the moment and be happy. The vicious circle of financial success and/or accolades never being enough.

02:22:46 - How to decide if you should have kids

02:25:13 - Peter’s Top 10 Supplements and Top 10 Dr*gs

02:29:35 - Peter's personal supplement stack and dr*g protocol

02:42:26 - Homocysteine reduction protocol

02:44:11 - Vitamin B6 deficiency paradoxically caused by Pyridoxine Hydrochloride supplementation

02:46:00 - How safe is TRT for cardiovascular health? TRAVERSE clinical trial results

02:51:31 - Comparison of TRT administration methods. What Peter prefers for patients

02:52:40 - What podcasts and YouTube channels Peter likes to watch or listen to

02:55:09 - Formula 1

02:55:54 - AlphaTauri x Hugo Boss

02:56:21 - Daniel Ricciardo, Max Verstappen

02:59:33 - How Red Bull became such a dominant F1 team

03:01:35 - Sim racing

03:05:13 - How Peter got so interested in F1

03:06:33 - Peter’s dream car

03:06:50 - Ayrton Senna

03:08:25 - Outro

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