Do You Know How to Precisely Correct a Jane?

If you're just trying to mess up a nucleus, it's not that pam dependent. But there aren't as many diseases that you can fix by messing up a jane as there are ones tat you can fixed by precisely correcting it with ta nucleus. There is a base editing window, which occurs roughly 15 plus or min to nucleasides from the pam. And so the location of the pam is important and can be limitidg with he base editor.