Itacitinib monotherapy for GVHD, the role of ERG in EVI1-driven AML, and germline DDX41 mutations in myeloid neoplasms
Blood Podcast
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EVI-1-Driven AML in Mirian AML Patients
The study looked at genes that are transcriptionally controlled by EVI-1. It identified ERG as the only transcription factor directly regulated by EVi-1. The major oncogenic functions ofEVI-1 are mediated through aberrant transcriptional activation of ERG, they say.
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