Systemic Schlorosis - The Pathogenesis of the Disease

The pathogenesis of systemic schlorosis is complex and not fully understood. But immune activation, vascular andothelial damage and excessive fibre blast activation all appear to be hall marks of the disease. Vascular jury causes endo thelial cells to release endo theLian one, a powerful vaso constrictor leading to increased vascular tone and fibre blast activation. Response to vascular injury also involves migration and hypertrophe of smooth muscle cells within blood vessel walls causing them to stiffen and narrow. There is also a powerful inflammatory and menologic response involving the release of many cito kinds,. The development of pro inflammatory mediators and the development of auto anti bodies in extra stellar metrix