A lot of people get worried about saturated fat when they have APOE4 alleles. To me, it's never made a whole lot of sense to think that our ancestors were eating a whole bunch of saturated fat from animal foods. If saturated fat makes up the majority of your calorie intake, I think that is a relatively novel exposure. But if you compare that to somebody on a modern ketogenic diet slamming heavy cream and butter all day, he says.

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