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IBCC Episode 112 - Valproic Acid Toxicity

The Internet Book of Critical Care Podcast

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Ammonia in Serosis

When all the other modes of metabolism are kind of saturated during intoxication, omega oxidation can occur. This is problematic becase it generates a variety of different toxic metabolites which can cause cerebral dema, hipato toxicity and hyperm miao. And the last one is when carnatine comes up, isn't it josh, what happens with conjugation and carnatine? Yes, valprot can get conjugated to carnatine, and that kind of combined valprit carnatine complex can be real excreted. That's not a huge mechanism for the excretion of valprat, but it can be important because it essentially depletes the body of

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